Could exposure to spaceflight cause mutations in genes that affect male fertility?
Life Sci Space Res (Amst)
; 37: 15-17, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-37087174
ABSTRACT
Recently, a study reported that upon analyzing blood samples from 14 astronauts that flew Space Transportation System missions between 1998 and 2001, 34 somatic nonsynonymous single nucleotide variants were detected in 17 CH-driver genes. Of interest is that the cohort consisted of relatively young astronauts, 85% of which were males of reproductive age. Having investigated the genes with nonsynonymous substitutes from the literature, it was found that twelve of these 17 genes appear to play essential roles in male reproduction. Changes in telomere length and gene regulation were also reported in another study conducted on an astronaut during a long duration stay on the International Space Station. Realizing the impact of spaceflight on gene sequence with potential influence on male fertility, it is important that more studies are conducted in this field. Specifically, in light of ultimately colonizing space, multi-generational survival is crucial and strategies to mitigate or counteract such effects should be explored.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Voo Espacial
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Life Sci Space Res (Amst)
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Emirados Árabes Unidos