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Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin-mediated deacetylation.
Mishra, Saurabh; Welch, Nicole; Karthikeyan, Manikandan; Bellar, Annette; Musich, Ryan; Singh, Shashi Shekhar; Zhang, Dongmei; Sekar, Jinendiran; Attaway, Amy H; Chelluboyina, Aruna Kumar; Lorkowski, Shuhui Wang; Roychowdhury, Sanjoy; Li, Ling; Willard, Belinda; Smith, Jonathan D; Hoppel, Charles L; Vachharajani, Vidula; Kumar, Avinash; Dasarathy, Srinivasan.
Afiliação
  • Mishra S; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Welch N; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Karthikeyan M; Departments of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USA.
  • Bellar A; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Musich R; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Singh SS; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Zhang D; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Sekar J; Proteomics and Metabolomics core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Attaway AH; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Chelluboyina AK; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Lorkowski SW; Departments of Pulmonary Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
  • Roychowdhury S; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Li L; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Willard B; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Smith JD; Proteomics and Metabolomics core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Hoppel CL; Proteomics and Metabolomics core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Vachharajani V; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Kumar A; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Dasarathy S; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Aging Cell ; 22(7): e13852, 2023 07.
Article em En | MEDLINE | ID: mdl-37101412
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperamonemia / Sirtuínas / Sirtuína 3 Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Aging Cell Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperamonemia / Sirtuínas / Sirtuína 3 Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Aging Cell Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos