A Novel Derivative of Curcumol, HCL-23, Inhibits the Malignant Phenotype of Triple-Negative Breast Cancer and Induces Apoptosis and HO-1-Dependent Ferroptosis.

Zhao, Peng; Song, Hui; Gao, Futian; Chen, Liang; Qiu, Jianfei; Jin, Jun; Pan, Chaolan; Tang, Yunyan; Chen, Meijun; Pan, Yang; Li, Yanmei; Huang, Liejun; Yang, Jue; Hao, Xiaojiang

Zhao, Peng; Song, Hui; Gao, Futian; Chen, Liang; Qiu, Jianfei; Jin, Jun; Pan, Chaolan; Tang, Yunyan; Chen, Meijun; Pan, Yang; Li, Yanmei; Huang, Liejun; Yang, Jue; Hao, Xiaojiang.

Afiliação

Zhao P; State Key Laboratory of Functions and Applications of Medicinal Plants & Key Laboratory of Endemic and Ethnic Diseases & Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang 550025, China.
Song H; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China.
Gao F; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.
Chen L; State Key Laboratory of Functions and Applications of Medicinal Plants & Key Laboratory of Endemic and Ethnic Diseases & Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang 550025, China.
Qiu J; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China.
Jin J; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China.
Pan C; Key Laboratory of Modern Pathogen Biology and Characteristics, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, China.
Tang Y; State Key Laboratory of Functions and Applications of Medicinal Plants & Key Laboratory of Endemic and Ethnic Diseases & Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang 550025, China.
Chen M; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China.
Pan Y; State Key Laboratory of Functions and Applications of Medicinal Plants & Key Laboratory of Endemic and Ethnic Diseases & Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang 550025, China.
Li Y; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China.
Huang L; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.
Yang J; State Key Laboratory of Functions and Applications of Medicinal Plants & Key Laboratory of Endemic and Ethnic Diseases & Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang 550025, China.
Hao X; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China.

Molecules ; 28(8)2023 Apr 12.

Article em En | MEDLINE | ID: mdl-37110625

Assuntos

Ferroptose; Neoplasias de Mama Triplo Negativas; Humanos; Animais; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Neoplasias de Mama Triplo Negativas/genética; Neoplasias de Mama Triplo Negativas/metabolismo; Heme Oxigenase-1/genética; Linhagem Celular Tumoral; Apoptose; Proliferação de Células

Palavras-chave

apoptosis; curcumol derivative; ferroptosis; metastasis; triple-negative breast cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas / Ferroptose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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