sCTX II is a better biomarker than sMMP-3 to identify early knee osteoarthritis.
J Orthop Res
; 41(11): 2455-2461, 2023 11.
Article
em En
| MEDLINE
| ID: mdl-37132376
ABSTRACT
The aim of this study is to assess the ability of serum MMP-3 and serum CTX-II levels to differentiate between normal and early knee osteoarthritis case (eKOA). Subjects with clinical features of primary knee osteoarthritis of K-L Grade I and K-L Grade II with ages more than 45 years were included in the case group (98), and healthy adults with ages less than 40 years were included in the control group (80). Those having knee pain for the last 3 months but having no radiological features were labeled as K-L grade I and those having minimal osteophytes on radiographs were labeled as K-L Grade II. Antero-posterior views of knee and serum levels of MMP-3 and CTX II were estimated. Cases show significantly higher values of both biomarkers than in controls (p < 0.0001). Both biomarkers show significantly higher values with an increase in K-L Grades, that is, K-L Grade 0 versus I (MMP-3 p = 0.003; CTX-II p = 0.002), K-L Grade I versus II (MMP-3 p < 0.000; CTX-II p < 0.000). Multivariate analysis shows the dependence of both biomarkers only on K-L Grades. ROC analysis suggests cutoff value between KL Grade 0 and Grade I (MMP-3 12.25 ng/mL; CTX II 407.50 pg/mL) and between K L Grade I and Grade II (MMP-3 18.37 ng/mL; CTX II 528.00 pg/mL). The discriminating ability of CTX II is superior between normal population and eKOA (CTX II Accuracy 66.83%, p = 0.0002; MMP-3 Accuracy 50.39%, p = 0.138), but MMP-3 is superior than CTX II between eKOA and mild KOA (CTX II67.52%, p < 0.000; MMP-3 70.69%, p < 0.000).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite do Joelho
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
J Orthop Res
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Índia