Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats.
Acta Cir Bras
; 38: e380223, 2023.
Article
em En
| MEDLINE
| ID: mdl-37132752
ABSTRACT
PURPOSE:
To explore the role and mechanism of curcumin (Cur) in reducing oxidative stress damage in rats with nephrolithiasis induced by ethylene glycol (EG).METHODS:
Thirty male rats were divided into normal control, model, positive (10% potassium citrate), Cur-10 (10 mg/kg curcumin) and Cur-20 (20 mg/kg curcumin) groups.RESULTS:
The results of kidney tissue section stained by hematoxylin-eosin and von Kossa showed that curcumin treatment can inhibit the formation of kidney stones. The biochemical test results showed that the urea (Ur), creatinine (Cr), uric acid (UA), inorganic phosphorus and Ca2+ concentrations in urine decreased after being treated with curcumin. There were significant differences between different doses of curcumin (P < 0.05). Compared with the Cur-10 group, Cur-20 had a more significant inhibitory effect on malondialdehyde (MDA) (P < 0.05). In addition, reverse transcription polymerase chain reaction (PCR) detection and immunohistochemical results indicated that the osteopontin (OPN) in the kidney was significantly reduced after curcumin treatment.CONCLUSIONS:
Curcumin could reduce the oxidative stress damage caused by EG-induced kidney stones.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálculos Renais
/
Curcumina
/
Osteopontina
Limite:
Animals
Idioma:
En
Revista:
Acta Cir Bras
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China