Effect of Different Carbons on Lipid Production and SNF1 Transcription in Mucor Circinelloides.
Indian J Microbiol
; 63(1): 146-151, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-37188240
ABSTRACT
Sucrose non-fermenting 1 (SNF1) protein kinase plays an important role in the utilization of selective carbon sources and regulation of lipid metabolism. In order to further explore the function of SNF1 in regulating lipid accumulation by responding nutritional signals from non-glucose carbon sources, in the present study, the lipid production and SNF1 transcriptional levels of Mucor circinelloides were analyzed and compared on different carbon sources. The results indicated that M. circinelloides could effectively utilize some secondary metabolic carbon sources of monosaccharides and disaccharides for growth and lipids production, such as fructose, maltose and galactose. Snf-ß subunit was associated with the regulation of lipid metabolism in response to nutritional signals from different carbon sources. This is the first report on the transcriptional analysis of SNF1 subunits on different carbons metabolism in oleaginous filamentous fungi. This research has suggested that genetic engineering of SNF1 subunits will alter the lipid production of M. circinelloides from alternative carbon sources. Supplementary Information The online version contains supplementary material available at 10.1007/s12088-023-01070-z.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Indian J Microbiol
Ano de publicação:
2023
Tipo de documento:
Article