Neuronal and astrocyte determinants of critical periods of plasticity.
Trends Neurosci
; 46(7): 566-580, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37202300
ABSTRACT
Windows of plasticity allow environmental experiences to produce intense activity-dependent changes during postnatal development. The reordering and refinement of neural connections occurs during these periods, significantly influencing the formation of brain circuits and physiological processes in adults. Recent advances have shed light on factors that determine the onset and duration of sensitive and critical periods of plasticity. Although GABAergic inhibition has classically been implicated in closing windows of plasticity, astrocytes and adenosinergic inhibition have also emerged more recently as key determinants of the duration of these periods of plasticity. Here, we review novel aspects of the involvement of GABAergic inhibition, the possible role of presynaptic NMDARs, and the emerging roles of astrocytes and adenosinergic inhibition in determining the duration of windows of plasticity in different brain regions.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Astrócitos
/
Plasticidade Neuronal
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Trends Neurosci
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Espanha