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Do immune checkpoint inhibitors share the same pharmacological feature in the risk of cardiac arrhythmias?
Mascolo, Annamaria; Sportiello, Liberata; Rafaniello, Concetta; Donniacuo, Maria; Ruggiero, Donatella; Scisciola, Lucia; Barbieri, Michelangela; Rossi, Francesco; Paolisso, Giuseppe; Capuano, Annalisa.
Afiliação
  • Mascolo A; Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Napoli, Italy; Department of Experimental Medicine - Section of Pharmacology "L. Donatelli", University of Campania "Luigi Vanvitelli", Napoli, Italy. Electronic address: annamaria.mascolo@unicampania.it.
  • Sportiello L; Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Napoli, Italy; Department of Experimental Medicine - Section of Pharmacology "L. Donatelli", University of Campania "Luigi Vanvitelli", Napoli, Italy.
  • Rafaniello C; Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Napoli, Italy; Department of Experimental Medicine - Section of Pharmacology "L. Donatelli", University of Campania "Luigi Vanvitelli", Napoli, Italy.
  • Donniacuo M; Department of Experimental Medicine - Section of Pharmacology "L. Donatelli", University of Campania "Luigi Vanvitelli", Napoli, Italy.
  • Ruggiero D; Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Napoli, Italy; Department of Experimental Medicine - Section of Pharmacology "L. Donatelli", University of Campania "Luigi Vanvitelli", Napoli, Italy.
  • Scisciola L; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Barbieri M; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Rossi F; Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Napoli, Italy; Department of Experimental Medicine - Section of Pharmacology "L. Donatelli", University of Campania "Luigi Vanvitelli", Napoli, Italy.
  • Paolisso G; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Capuano A; Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Napoli, Italy; Department of Experimental Medicine - Section of Pharmacology "L. Donatelli", University of Campania "Luigi Vanvitelli", Napoli, Italy.
Biomed Pharmacother ; 164: 114912, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37210896
BACKGROUND: Despite the available evidence showing an association between cardiac arrhythmia and Immune Checkpoint Inhibitors (ICIs), few studies have compared this risk between ICIs. OBJECTIVES: We aim to evaluate Individual Case Safety Reports (ICSRs) of ICIs-induced cardiac arrhythmias and compare the reporting frequency of cardiac arrhythmias among ICIs. METHODS: ICSRs were retrieved from the European Pharmacovigilance database (Eudravigilance). ICSRs were classified based on the ICI reported (pembrolizumab, nivolumab, atezolizumab, ipilimumab, durvalumab, avelumab, cemiplimab, and dostarlimab). If more than one ICI was reported, the ICSR was classified as a combination of ICIs. ICSRs of ICI-related arrhythmias were described and the reporting frequency of cardiac arrhythmias was assessed by applying the reporting odds ratio (ROR) and its 95 % confidence interval (95 %CI). RESULTS: A total of 1262 ICSRs were retrieved, of which 147 (11.65 %) were related to combinations of ICIs. A total of 1426 events of cardiac arrhythmias were identified. The three most reported events were atrial fibrillation, tachycardia, and cardiac arrest. Ipilimumab was associated with a reduced reporting frequency of cardiac arrhythmias compared to all other ICIs (ROR 0.71, 95 %CI 0.55-0.92; p = 0.009). Anti-PD1 was associated with a higher reporting frequency of cardiac arrhythmias than anti-CTLA4 (ROR 1.47, 95 %CI 1.14-1.90; p = 0.003). CONCLUSION: This study is the first comparing ICIs for the risk of cardiac arrhythmias. We found that ipilimumab was the only ICI associated with a reduced reporting frequency. Further high-quality studies are needed to confirm our results.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Antineoplásicos Imunológicos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Antineoplásicos Imunológicos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article