Study protocol of an open-label, single arm phase II trial investigating the efficacy and safety of Trifluridine/Tipiracil combined with irinotecan as a second line therapy in patients with cholangiocarcinoma (TRITICC).

Kehmann, Linde; Berres, Marie-Luise; Gonzalez-Carmona, Maria; Modest, Dominik P; Mohr, Raphael; Wree, Alexander; Venerito, Marino; Strassburg, Christian; Keitel, Verena; Trautwein, Christian; Luedde, Tom; Roderburg, Christoph

Kehmann, Linde; Berres, Marie-Luise; Gonzalez-Carmona, Maria; Modest, Dominik P; Mohr, Raphael; Wree, Alexander; Venerito, Marino; Strassburg, Christian; Keitel, Verena; Trautwein, Christian; Luedde, Tom; Roderburg, Christoph.

Afiliação

Kehmann L; Department of Hepatology and Gastroenterology, Campus Virchow Klinikum, Charité University Medicine Berlin, 13353, Berlin, Germany.
Berres ML; Servier Deutschland GmbH, Elsenheimerstr, 53, 80687, München, Germany.
Gonzalez-Carmona M; Medical Department III, University Hospital of Aachen, Aachen, 52074, Germany.
Modest DP; Department of Internal Medicine I, University Hospital of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Mohr R; Department of Hematology, Oncology and Tumorimmunology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, 10117, Berlin, Germany.
Wree A; Department of Hepatology and Gastroenterology, Campus Virchow Klinikum, Charité University Medicine Berlin, 13353, Berlin, Germany.
Venerito M; Department of Hepatology and Gastroenterology, Campus Virchow Klinikum, Charité University Medicine Berlin, 13353, Berlin, Germany.
Strassburg C; Department of Gastroenterology, Hepatology & Infectious Diseases, Otto-Von-Guericke University Hospital, 39120, Magdeburg, Germany.
Keitel V; Department of Internal Medicine I, University Hospital of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Trautwein C; Department of Gastroenterology, Hepatology & Infectious Diseases, Otto-Von-Guericke University Hospital, 39120, Magdeburg, Germany.
Luedde T; Medical Department III, University Hospital of Aachen, Aachen, 52074, Germany.
Roderburg C; Clinic for Gastroenterology, Hepatology & Infectious Diseases, University Hospital of Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.

BMC Cancer ; 23(1): 470, 2023 May 22.

Article em En | MEDLINE | ID: mdl-37217885

Assuntos

Neoplasias dos Ductos Biliares; Neoplasias do Sistema Biliar; Colangiocarcinoma; Neoplasias Colorretais; Demência Frontotemporal; Adulto; Humanos; Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Neoplasias dos Ductos Biliares/tratamento farmacológico; Neoplasias dos Ductos Biliares/etiologia; Ductos Biliares Intra-Hepáticos/patologia; Neoplasias do Sistema Biliar/tratamento farmacológico; Colangiocarcinoma/tratamento farmacológico; Colangiocarcinoma/etiologia; Cisplatino; Ensaios Clínicos Fase II como Assunto; Neoplasias Colorretais/patologia; Desoxicitidina; Progressão da Doença; Demência Frontotemporal/induzido quimicamente; Demência Frontotemporal/tratamento farmacológico; Gencitabina; Irinotecano; Estudos Prospectivos; Trifluridina/efeitos adversos; Estudos Multicêntricos como Assunto

Palavras-chave

Biliary tract cancer; Chemotherapy; Cholangiocarcinoma; FTD/TPI (Trifluridine/Tipiracil); Gall bladder carcinoma; Irinotecan; Second-line treatment; Translational research

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias dos Ductos Biliares / Neoplasias do Sistema Biliar / Neoplasias Colorretais / Colangiocarcinoma / Demência Frontotemporal Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

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