Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene Cohort.
Medicina (Kaunas)
; 59(5)2023 May 18.
Article
em En
| MEDLINE
| ID: mdl-37241208
ABSTRACT
Background and objectives:
Chronic obstructive pulmonary disease (COPD) is usually comorbid with other chronic diseases. We aimed to assess the multimorbidity medication patterns and explore if the patterns are similar for phase 1 (P1) and 5-year follow-up phase 2 (P2) in the COPDGene cohort. Materials andMethods:
A total of 5564 out of 10,198 smokers from the COPDGene cohort who completed 2 visits, P1 and P2 visits, with complete medication use history were included in the study. We conducted latent class analysis (LCA) among the 27 categories of chronic disease medications, excluding COPD treatments and cancer medications at P1 and P2 separately. The best number of LCA classes was determined through both statistical fit and interpretation of the patterns.Results:
We found four classes of medication patterns at both phases. LCA showed that both phases shared similar characteristics in their medication patterns LC0 low medication; LC1 hypertension (HTN) or cardiovascular disease (CVD)+high cholesterol (Hychol) medication predominant; LC2 HTN/CVD+type 2 diabetes (T2D) +Hychol medication predominant; LC3 Hychol medication predominant.Conclusions:
We found similar multimorbidity medication patterns among smokers at P1 and P2 in the COPDGene cohort, which provides an understanding of how multimorbidity medication clustered and how different chronic diseases combine in smokers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Doença Pulmonar Obstrutiva Crônica
/
Diabetes Mellitus Tipo 2
/
Hiperlipidemias
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Medicina (Kaunas)
Assunto da revista:
MEDICINA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos