Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer's disease? From preclinical studies to the clinical trials.

Basheer, Neha; Smolek, Tomás; Hassan, Imtaiyaz; Liu, Fei; Iqbal, Khalid; Zilka, Norbert; Novak, Petr

Basheer, Neha; Smolek, Tomás; Hassan, Imtaiyaz; Liu, Fei; Iqbal, Khalid; Zilka, Norbert; Novak, Petr.

Afiliação

Basheer N; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, 845 10, Slovakia.
Smolek T; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, 845 10, Slovakia.
Hassan I; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Liu F; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA.
Iqbal K; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA.
Zilka N; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, 845 10, Slovakia. norbert.zilka@savba.sk.
Novak P; AXON Neuroscience R&D Services SE, Bratislava, 811 02, Slovakia. norbert.zilka@savba.sk.

Mol Psychiatry ; 28(6): 2197-2214, 2023 06.

Article em En | MEDLINE | ID: mdl-37264120

Assuntos

Doença de Alzheimer; Tauopatias; Humanos; Doença de Alzheimer/metabolismo; Proteínas tau/metabolismo; Fosforilação; Tauopatias/tratamento farmacológico; Proteína Fosfatase 2; Proteínas Quinases/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tauopatias / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Eslováquia

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