Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using &#945;-synuclein triplication Parkinson's disease patient-derived iPSCs.

Patikas, Nikolaos; Ansari, Rizwan; Metzakopian, Emmanouil

Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson's disease patient-derived iPSCs.

Patikas, Nikolaos; Ansari, Rizwan; Metzakopian, Emmanouil.

Afiliação

Patikas N; UK Dementia Research Institute, Department of Clinical Neurosciences, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: npatikas@bwh.harvard.edu.
Ansari R; UK Dementia Research Institute, Department of Clinical Neurosciences, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AH, UK.
Metzakopian E; UK Dementia Research Institute, Department of Clinical Neurosciences, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: em698@medschl.cam.ac.uk.

Neurosci Res ; 195: 13-28, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37271312

Assuntos

Células-Tronco Pluripotentes Induzidas; Doença de Parkinson; Humanos; Doença de Parkinson/genética; Doença de Parkinson/metabolismo; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo; Transcriptoma; Diferenciação Celular; Neurônios Dopaminérgicos/metabolismo; Mesencéfalo; Organoides

Palavras-chave

Chimera; IPSC; Midbrain organoids; Oxidative-stress; Parkinson's disease; SNCA; ScRNAseq; αSynuclein

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Neurosci Res Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google