[Mechanism of Synthesis and Effect of Autoantibodies: Implications for Therapy].

The detailed mechanisms of autoantibody synthesis are different in each disease; however, the dysfunction of immune tolerance is attracting interest as the common mechanism in many autoantibody-associated diseases. Autoantibodies must pass through various physiological barriers, such as the blood-brain barrier, to approach their antigen in the central nervous system. The direct effects of autoantibodies on their antigens vary among antibodies. Exploring the detailed mechanism of synthesis and effect of autoantibodies would provide a more radical and effective therapeutic strategy.