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The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases-A Review.
Dopytalska, Klaudia; Czaplicka, Anna; Szymanska, Elzbieta; Walecka, Irena.
Afiliação
  • Dopytalska K; Department of Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, Poland.
  • Czaplicka A; Department of Dermatology, The National Institute of Medicine of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland.
  • Szymanska E; Department of Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, Poland.
  • Walecka I; Department of Dermatology, The National Institute of Medicine of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland.
Int J Mol Sci ; 24(11)2023 May 23.
Article em En | MEDLINE | ID: mdl-37298095
ABSTRACT
The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs-non-coding RNAs), are one of the important post-transcriptional epigenetic factors. miRNAs have a significant role in the regulation of the immune response by participating in the process of the differentiation and activation of B and T lymphocytes, macrophages, and dendritic cells. Recent advances in research on epigenetic factors have provided new insights into the pathogenesis and potential diagnostic and therapeutic targets of many pathologies. Numerous studies revealed a change in the expression of some microRNAs in inflammatory skin disorders, and the regulation of miRNA expression is a promising therapeutic goal. This review presents the state of the art regarding changes in the expression and role of miRNAs in inflammatory and autoimmune skin diseases, including psoriasis, atopic dermatitis, vitiligo, lichen planus, hidradenitis suppurativa, and autoimmune blistering diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Doenças Autoimunes / Hidradenite Supurativa / MicroRNAs / Dermatite Atópica Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Doenças Autoimunes / Hidradenite Supurativa / MicroRNAs / Dermatite Atópica Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia