Cell-center-based model for simulating three-dimensional monolayer tissue deformation.
J Theor Biol
; 571: 111560, 2023 08 21.
Article
em En
| MEDLINE
| ID: mdl-37315765
ABSTRACT
The shape of the epithelial monolayer can be depicted as a curved tissue in three-dimensional (3D) space, where individual cells are tightly adhered to one another. The 3D morphogenesis of these tissues is governed by cell dynamics, and a variety of mathematical modeling and simulation studies have been conducted to investigate this process. One promising approach is the cell-center model, which can account for the discreteness of cells. The cell nucleus, which is considered to correspond to the cell center, can be observed experimentally. However, there has been a shortage of cell-center models specifically tailored for simulating 3D monolayer tissue deformation. In this study, we developed a mathematical model based on the cell-center model to simulate 3D monolayer tissue deformation. Our model was confirmed by simulating the in-plane deformation, out-of-plane deformation, and invagination due to apical constriction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Modelos Biológicos
/
Modelos Teóricos
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
2023
Tipo de documento:
Article