Review on adherence of the literature to official recommendations on albuminuria harmonization and standardization.
Clin Chem Lab Med
; 61(12): 2076-2083, 2023 11 27.
Article
em En
| MEDLINE
| ID: mdl-37325992
ABSTRACT
Albuminuria standardization is a key issue to produce reliable and equivalent results between laboratories. We investigated whether official recommendations on albuminuria harmonization are followed in the literature. The PubMed database was searched from June 1 to September 26, 2021. The search terms included urine albumin, urine albumin-to-creatinine ratio (uACR), and albuminuria. A total of 159 articles were considered eligible; 50.9â¯% reported the type of urine collection. Specifically, 58.1â¯% collected a random spot urine specimen, 21â¯% collected a first morning void, and 6.2â¯% collected a 24-h specimen. Overall, 15â¯% of articles reported data on sample shipping, storage, and centrifugation and 13.3â¯% mentioned the preanalytical phase without any data on albuminuria. The method for albuminuria was properly described in 31.4â¯% of articles; of these, 54.9â¯% used immunological methods, and 8.9â¯% contained errors or missing data. Most articles (76.7â¯%) expressed test results as albuminuria-to-creatininuria ratio. Different decision levels were utilized in 130 articles; of these, 36â¯% used a decision level of ≤30â¯mg/g creatininuria and 23.7â¯% used three decision levels (≤30, 30-300, and ≥300â¯mg/g). The failure to follow guidelines on albuminuria harmonization was mainly found in the preanalytical phase. The poor awareness of the importance of preanalytical steps on test result may be a possible explanation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Urinálise
/
Albuminúria
Limite:
Humans
Idioma:
En
Revista:
Clin Chem Lab Med
Assunto da revista:
QUIMICA CLINICA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália