The association of hypoxia-inducible factor-1α and hypoxia-inducible factor-2α protein expression with clinicopathological characteristics in papillary thyroid carcinoma: A meta-analysis.
Medicine (Baltimore)
; 102(24): e34045, 2023 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-37327294
ABSTRACT
OBJECTIVE:
To investigate the correlation of hypoxia-inducible factor-1α (HIF-1α) and hypoxia-inducible factor-2α (HIF-2α) protein expression with clinicopathologic characteristics in patients with papillary thyroid carcinoma (PTC) through a meta-analysis.METHODS:
PubMed, Embase, Web of Science, Cochrane, CNKI, Wanfang, and VIP databases were searched from the establishment of the database to February 2023. The New castle-Ottawa Scale was used to evaluate the quality of the literature. Rev Man 5.3 and Stata14.0 were used to conduct a meta-analysis of the included studies.RESULTS:
Twenty-eight articles with 2346 samples were included in the Meta-analysis. Compared with normal thyroid tissues, HIF-1α and HIF-2α proteins were highly expressed in PTC tumor tissues. High expression of HIF-1α protein was associated with tumor size (odds ratio [OR]â =â 4.50, 95% confidence interval [CI] 2.88-7.04, Pâ <â .00001), lymph node metastasis (ORâ =â 4.76, 95% CI 3.78-5.99, Pâ <â .00001), TNM stage (ORâ =â 3.67, 95% CI 2.68-5.03, Pâ <â .00001), capsular invasion (ORâ =â 2.30, 95% CI 1.43-3.71, Pâ =â .0006â <â .05), and extrathyroidal extension (ORâ =â 10.96, 95% CI 4.80-25.02, Pâ <â .00001). High expression of HIF-2α protein was associated with lymph node metastasis (ORâ =â 4.18, 95% CI 2.63-6.65, Pâ <â .00001), TNM stage (ORâ =â 2.56, 95% CI 1.36-4.82, Pâ =â .004â <â .05), and capsular invasion (ORâ =â 3.84, 95% CI 1.66-8.88, Pâ =â .002â <â .05). In addition, we concluded for the first time that there was a statistically significant difference in the expression of HIF-1α and HIF-2α in PTC patients (ORâ =â 2.36, 95% CI 1.26-4.42, Pâ =â .007â <â .05).CONCLUSIONS:
The high expression of HIF-1α and HIF-2α proteins is closely related to some clinicopathological parameters of PTC, and can provide potential biological indicators for the diagnosis and prognosis of PTC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China