Chromodomain helicase DNA binding protein 4 in cell fate decisions.
Hear Res
; 436: 108813, 2023 09 01.
Article
em En
| MEDLINE
| ID: mdl-37329862
ABSTRACT
Loss of spiral ganglion neurons (SGNs) in the cochlea causes hearing loss. Understanding the mechanisms of cell fate transition accelerates efforts that employ directed differentiation and lineage conversion to repopulate lost SGNs. Proposed strategies to regenerate SGNs rely on altering cell fate by activating transcriptional regulatory networks, but repressing networks for alternative cell lineages is also essential. Epigenomic changes during cell fate transitions suggest that CHD4 represses gene expression by altering the chromatin status. Despite limited direct investigations, human genetic studies implicate CHD4 function in the inner ear. The possibility of CHD4 in suppressing alternative cell fates to promote inner ear regeneration is discussed.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Perda Auditiva Neurossensorial
/
Orelha Interna
Limite:
Humans
Idioma:
En
Revista:
Hear Res
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos