Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond.

Bodescu, Mihai Adrian; Aretz, Jonas; Grison, Marco; Rief, Matthias; Fässler, Reinhard

Bodescu, Mihai Adrian; Aretz, Jonas; Grison, Marco; Rief, Matthias; Fässler, Reinhard.

Afiliação

Bodescu MA; Center for Protein Assemblies and TUM School of Natural Sciences, Department of Bioscience, Chair of Molecular Biophysics, Technical University of Munich, Garching 85748, Germany.
Aretz J; Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
Grison M; Center for Protein Assemblies and TUM School of Natural Sciences, Department of Bioscience, Chair of Molecular Biophysics, Technical University of Munich, Garching 85748, Germany.
Rief M; Center for Protein Assemblies and TUM School of Natural Sciences, Department of Bioscience, Chair of Molecular Biophysics, Technical University of Munich, Garching 85748, Germany.
Fässler R; Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.

Proc Natl Acad Sci U S A ; 120(26): e2218116120, 2023 06 27.

Article em En | MEDLINE | ID: mdl-37339195

Assuntos

Integrinas; Talina; Animais; Talina/metabolismo; Ligantes; Proteínas de Membrana/metabolismo; Adesão Celular

Palavras-chave

focal adhesion; ideal bond; integrins; optical tweezers; single-molecule

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Integrinas / Talina Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

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