Novel Antimurine Thyroid-Stimulating Hormone Receptor Monoclonal Antibodies.
Monoclon Antib Immunodiagn Immunother
; 42(3): 109-114, 2023 Jun.
Article
em En
| MEDLINE
| ID: mdl-37343169
ABSTRACT
Autoantibodies against thyroid proteins are present in several thyroid diseases. Thyroid-stimulating hormone receptor (TSHR) is a G-protein-coupled receptor (GPCR) that binds to thyroid-stimulating hormone (TSH) and stimulates production of thyroxine (T4) and triiodothyronine (T3). When agonized by anti-TSHR autoantibodies, aberrant production of thyroid hormone can lead to Graves' Disease (GD). In Hashimoto's thyroiditis (HT), anti-TSHR autoantibodies target the thyroid for immune attack. To better understand the role of anti-TSHR antibodies in thyroid disease, we generated a set of rat antimouse (m)TSHR monoclonal antibodies with a range of affinities, blocking of TSH, and agonist activity. These antibodies could be used to investigate the etiology and therapy of thyroid disease in mouse models and as building blocks in protein therapeutics that target the thyroid for treatment in either HT or GD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Graves
/
Doença de Hashimoto
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Monoclon Antib Immunodiagn Immunother
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos