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What the BTBR/J mouse has taught us about diabetes and diabetic complications.
Keller, Mark P; Hudkins, Kelly L; Shalev, Anath; Bhatnagar, Sushant; Kebede, Melkam A; Merrins, Matthew J; Davis, Dawn Belt; Alpers, Charles E; Kimple, Michelle E; Attie, Alan D.
Afiliação
  • Keller MP; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • Hudkins KL; Department of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
  • Shalev A; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, UK.
  • Bhatnagar S; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, UK.
  • Kebede MA; School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Camperdown, Sydney, NSW 2006, Australia.
  • Merrins MJ; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
  • Davis DB; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.
  • Alpers CE; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
  • Kimple ME; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.
  • Attie AD; Department of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
iScience ; 26(7): 107036, 2023 Jul 21.
Article em En | MEDLINE | ID: mdl-37360692
ABSTRACT
Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lepob mutation. We went on to discover that the BTBR-Lepob mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos