LACC1: A critical involvement in macrophage immunometabolism.
Cell Biol Int
; 47(9): 1488-1490, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37366569
ABSTRACT
Laccase domain-containing 1 (LACC1) protein is an enzyme highly expressed in inflammatory macrophages, and studies have shown that it has a key role in diseases such as inflammatory bowel disease, arthritis, and microbial infections. Therefore, in this review, we focus on LACC1-mediated catalysis. In detail, LACC1 converts l-CITrulline (l-CIT) to l-ORNithine (l-ORN) and isocyanic acid in mice and humans and acts as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism, thus exerting anti-inflammatory and antibacterial effects. Considering the actions of LACC1, targeting LACC1 may be a potent therapeutic avenue for inflammation-related diseases and microbial infection diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite
/
Doenças Inflamatórias Intestinais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Biol Int
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China