Comparative assessment of Ca<sup>2+</sup> oscillations in 2- and 3-dimensional hiPSC derived and isolated cortical neuronal networks.

Imredy, John P; Roussignol, Gautier; Clouse, Holly; Salvagiotto, Giorgia; Mazelin-Winum, Ludmilla

Comparative assessment of Ca²⁺ oscillations in 2- and 3-dimensional hiPSC derived and isolated cortical neuronal networks.

Imredy, John P; Roussignol, Gautier; Clouse, Holly; Salvagiotto, Giorgia; Mazelin-Winum, Ludmilla.

Afiliação

Imredy JP; In Vitro Safety Pharmacology, Merck & Co., Inc., Rahway, NJ, USA. Electronic address: john_imredy@merck.com.
Roussignol G; Preclinical Safety, Sanofi R&D, Montpellier, France.
Clouse H; In Vitro Safety Pharmacology, Merck & Co., Inc., Rahway, NJ, USA.
Salvagiotto G; Fujifilm Cellular Dynamics, Inc., Madison, WI, USA.
Mazelin-Winum L; Preclinical Safety, Sanofi R&D, Montpellier, France.

J Pharmacol Toxicol Methods ; 123: 107281, 2023.

Article em En | MEDLINE | ID: mdl-37390871

Assuntos

Células-Tronco Pluripotentes Induzidas; Humanos; Camundongos; Animais; Células Cultivadas; Reprodutibilidade dos Testes; Neurônios; Descoberta de Drogas; Diferenciação Celular

Palavras-chave

Calcium; Cortical neuron; In vitro; Methods; Mouse; Networks; Neurons; Neurotoxicity; Safety pharmacology; Seizures; hiPSC

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article

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