Your browser doesn't support javascript.
loading
Venetoclax abrogates the prognostic impact of splicing factor gene mutations in newly diagnosed acute myeloid leukemia.
Senapati, Jayastu; Urrutia, Samuel; Loghavi, Sanam; Short, Nicholas J; Issa, Ghayas C; Maiti, Abhishek; Abbas, Hussein A; Daver, Naval G; Pemmaraju, Naveen; Pierce, Sherry; Chien, Kelly S; Sasaki, Koji; Kadia, Tapan M; Hammond, Danielle E; Borthakur, Gautam; Patel, Keyur; Ravandi, Farhad; Kantarjian, Hagop M; Garcia-Manero, Guillermo; DiNardo, Courtney D.
Afiliação
  • Senapati J; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Urrutia S; Department of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Loghavi S; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Short NJ; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Issa GC; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Maiti A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Abbas HA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Daver NG; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Pemmaraju N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Pierce S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Chien KS; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Sasaki K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Kadia TM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Hammond DE; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Borthakur G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Patel K; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Ravandi F; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Kantarjian HM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Garcia-Manero G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • DiNardo CD; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Blood ; 142(19): 1647-1657, 2023 11 09.
Article em En | MEDLINE | ID: mdl-37441846
Mutations in splicing factor (SF) genes SRSF2, U2AF1, SF3B1, and ZRSR2 are now considered adverse risk in the European LeukemiaNet 2022 acute myeloid leukemia (AML) risk stratification. The prognostic impact of SF mutations in AML has been predominantly derived from younger patients treated with intensive (INT) therapy. We evaluated 994 patients with newly diagnosed AML, including 266 (27%) with a SFmut. Median age was 67 years overall, with patients with SFmut being older at 72 years. SRSF2 (n = 140, 53%) was the most common SFmut. In patients treated with INT, median relapse-free survival (RFS) (9.6 vs 21.4 months, P = .04) and overall survival (OS) (15.9 vs 26.7 months, P = .06) were shorter for patients with SFmut than without SFwt, however this significance abrogated when evaluating patients who received venetoclax with INT therapy (RFS 15.4 vs 20.3 months, P = .36; OS 19.6 vs 30.7 months, P = .98). In patients treated with LI, median RFS (9.3 vs 7.7 months, P = .35) and OS (12.3 vs 8.5 months, P = .14) were similar for patients with and without SFmut , and outcomes improved in all groups with venetoclax. On multivariate analysis, SFmut did not affect hazards of relapse and death for INT arm but reduced both these hazards in LI arm. In a large AML data set with >60% of patients receiving venetoclax with LI/INT therapy, SFmut had no independent negative prognostic impact. Newer prognostic models that consider LI therapy and use of venetoclax among other factors are warranted.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Humans Idioma: En Revista: Blood Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Humans Idioma: En Revista: Blood Ano de publicação: 2023 Tipo de documento: Article