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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases.
Weeks, Elle M; Ulirsch, Jacob C; Cheng, Nathan Y; Trippe, Brian L; Fine, Rebecca S; Miao, Jenkai; Patwardhan, Tejal A; Kanai, Masahiro; Nasser, Joseph; Fulco, Charles P; Tashman, Katherine C; Aguet, Francois; Li, Taibo; Ordovas-Montanes, Jose; Smillie, Christopher S; Biton, Moshe; Shalek, Alex K; Ananthakrishnan, Ashwin N; Xavier, Ramnik J; Regev, Aviv; Gupta, Rajat M; Lage, Kasper; Ardlie, Kristin G; Hirschhorn, Joel N; Lander, Eric S; Engreitz, Jesse M; Finucane, Hilary K.
Afiliação
  • Weeks EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. eweeks@broadinstitute.org.
  • Ulirsch JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Cheng NY; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
  • Trippe BL; Artificial Intelligence Laboratory, Illumina, Inc., San Diego, CA, USA.
  • Fine RS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Miao J; Program in Computational & Systems Biology, MIT, Cambridge, MA, USA.
  • Patwardhan TA; Computer Science & Artificial Intelligence Lab, MIT, Cambridge, MA, USA.
  • Kanai M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Nasser J; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.
  • Fulco CP; Department of Genetics, Harvard Medical School, Boston, MA, USA.
  • Tashman KC; Vertex Pharmaceuticals Incorporated, Boston, MA, USA.
  • Aguet F; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Li T; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.
  • Ordovas-Montanes J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Smillie CS; Department of Statistics, Harvard University, Cambridge, MA, USA.
  • Biton M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Shalek AK; Analytic and Translational Genetics Unit, MGH, Boston, MA, USA.
  • Ananthakrishnan AN; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.
  • Xavier RJ; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
  • Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Gupta RM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lage K; Bristol Myers Squibb, Cambridge, MA, USA.
  • Ardlie KG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Hirschhorn JN; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Engreitz JM; MD-PhD Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nat Genet ; 55(8): 1267-1276, 2023 08.
Article em En | MEDLINE | ID: mdl-37443254
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Herança Multifatorial / Locos de Características Quantitativas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Herança Multifatorial / Locos de Características Quantitativas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos