Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.

Shaw, Daniel J; Waters, Lorna C; Strong, Sarah L; Schulze, Monika-Sarah E D; Greetham, Gregory M; Towrie, Mike; Parker, Anthony W; Prosser, Christine E; Henry, Alistair J; Lawson, Alastair D G; Carr, Mark D; Taylor, Richard J; Hunt, Neil T; Muskett, Frederick W

Shaw, Daniel J; Waters, Lorna C; Strong, Sarah L; Schulze, Monika-Sarah E D; Greetham, Gregory M; Towrie, Mike; Parker, Anthony W; Prosser, Christine E; Henry, Alistair J; Lawson, Alastair D G; Carr, Mark D; Taylor, Richard J; Hunt, Neil T; Muskett, Frederick W.

Afiliação

Shaw DJ; Department of Chemistry and York Biomedical Research Institute, University of York Heslington York YO19 5DD UK neil.hunt@york.ac.uk.
Waters LC; Department of Molecular and Cell Biology/Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road Leicester LE1 7RH UK fwm1@leicester.ac.uk.
Strong SL; Department of Molecular and Cell Biology/Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road Leicester LE1 7RH UK fwm1@leicester.ac.uk.
Schulze MED; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK.
Greetham GM; Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory Harwell Oxford Didcot Oxon OX11 0QX UK.
Towrie M; Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory Harwell Oxford Didcot Oxon OX11 0QX UK.
Parker AW; Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory Harwell Oxford Didcot Oxon OX11 0QX UK.
Prosser CE; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK.
Henry AJ; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK.
Lawson ADG; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK.
Carr MD; Department of Molecular and Cell Biology/Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road Leicester LE1 7RH UK fwm1@leicester.ac.uk.
Taylor RJ; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK.
Hunt NT; Department of Chemistry and York Biomedical Research Institute, University of York Heslington York YO19 5DD UK neil.hunt@york.ac.uk.
Muskett FW; Department of Molecular and Cell Biology/Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road Leicester LE1 7RH UK fwm1@leicester.ac.uk.

Chem Sci ; 14(27): 7524-7536, 2023 Jul 12.

Article em En | MEDLINE | ID: mdl-37449080

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Chem Sci Ano de publicação: 2023 Tipo de documento: Article

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