An electrophilic fragment screening for the development of small molecules targeting caspase-2.

Cuellar, Matthew E; Yang, Mu; Karavadhi, Surendra; Zhang, Ya-Qin; Zhu, Hu; Sun, Hongmao; Shen, Min; Hall, Matthew D; Patnaik, Samarjit; Ashe, Karen H; Walters, Michael A; Pockes, Steffen

Cuellar, Matthew E; Yang, Mu; Karavadhi, Surendra; Zhang, Ya-Qin; Zhu, Hu; Sun, Hongmao; Shen, Min; Hall, Matthew D; Patnaik, Samarjit; Ashe, Karen H; Walters, Michael A; Pockes, Steffen.

Afiliação

Cuellar ME; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, 55414, USA.
Yang M; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, 55414, USA.
Karavadhi S; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Zhang YQ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Zhu H; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Sun H; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Patnaik S; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Ashe KH; Department of Neurology, University of Minnesota, 2101 6th Street SE, Minneapolis, MN, 55455, USA.
Walters MA; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, 55414, USA. Electronic address: mwalters@umn.edu.
Pockes S; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, 55414, USA; Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany. Electronic address: steffen.pockes@ur.de.

Eur J Med Chem ; 259: 115632, 2023 Nov 05.

Article em En | MEDLINE | ID: mdl-37453329

Assuntos

Caspase 2; Inibidores de Caspase; Caspase 2/metabolismo; Caspase 3/metabolismo; Domínio Catalítico; Inibidores de Caspase/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Caspase 2 / Inibidores de Caspase Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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