Progressive human-like tauopathy with downstream neurodegeneration and neurovascular compromise in a transgenic rat model.

Emmerson, Joshua T; Do Carmo, Sonia; Liu, Yingying; Shalhoub, Ali; Liu, Ai; Bonomo, Quentin; Malcolm, Janice C; Breuillaud, Lionel; Cuello, A Claudio

Emmerson, Joshua T; Do Carmo, Sonia; Liu, Yingying; Shalhoub, Ali; Liu, Ai; Bonomo, Quentin; Malcolm, Janice C; Breuillaud, Lionel; Cuello, A Claudio.

Afiliação

Emmerson JT; Department of Pharmacology & Therapeutics, McGill University, Montreal H3G1Y6, Canada.
Do Carmo S; Department of Pharmacology & Therapeutics, McGill University, Montreal H3G1Y6, Canada.
Liu Y; Department of Pharmacology & Therapeutics, McGill University, Montreal H3G1Y6, Canada.
Shalhoub A; Department of Biochemistry, McGill University, Montreal H3A 0C7, Canada.
Liu A; Integrated Program in Neuroscience, McGill University, Montreal H3A 1A1, Canada.
Bonomo Q; Integrated Program in Neuroscience, McGill University, Montreal H3A 1A1, Canada.
Malcolm JC; Department of Anatomy and Cell Biology, McGill University, Montreal H3A 0C7, Canada.
Breuillaud L; Department of Pharmacology & Therapeutics, McGill University, Montreal H3G1Y6, Canada.
Cuello AC; Department of Pharmacology & Therapeutics, McGill University, Montreal H3G1Y6, Canada; Integrated Program in Neuroscience, McGill University, Montreal H3A 1A1, Canada; Department of Pharmacology, Oxford University, Oxford OX13QT, UK. Electronic address: claudio.cuello@mcgill.ca.

Neurobiol Dis ; 184: 106227, 2023 08.

Article em En | MEDLINE | ID: mdl-37454780

Assuntos

Doença de Alzheimer; Demência Frontotemporal; Doença de Pick; Tauopatias; Camundongos; Humanos; Ratos; Animais; Idoso; Ratos Transgênicos; Proteínas tau/genética; Demência Frontotemporal/patologia; Camundongos Transgênicos; Tauopatias/patologia; Doença de Alzheimer/patologia; Emaranhados Neurofibrilares/patologia; Modelos Animais de Doenças

Palavras-chave

human tauopathy; neurofibrillary tangles; neurovascular compromise; transgenic rat model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Pick / Tauopatias / Demência Frontotemporal / Doença de Alzheimer Limite: Aged / Animals / Humans Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

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