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The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells.
Brina, Daniela; Ponzoni, Adele; Troiani, Martina; Calì, Bianca; Pasquini, Emiliano; Attanasio, Giuseppe; Mosole, Simone; Mirenda, Michela; D'Ambrosio, Mariantonietta; Colucci, Manuel; Guccini, Ilaria; Revandkar, Ajinkya; Alajati, Abdullah; Tebaldi, Toma; Donzel, Deborah; Lauria, Fabio; Parhizgari, Nahjme; Valdata, Aurora; Maddalena, Martino; Calcinotto, Arianna; Bolis, Marco; Rinaldi, Andrea; Barry, Simon; Rüschoff, Jan Hendrik; Sabbadin, Marianna; Sumanasuriya, Semini; Crespo, Mateus; Sharp, Adam; Yuan, Wei; Grinu, Mathew; Boyle, Alexandra; Miller, Cynthia; Trotman, Lloyd; Delaleu, Nicolas; Fassan, Matteo; Moch, Holger; Viero, Gabriella; de Bono, Johann; Alimonti, Andrea.
Afiliação
  • Brina D; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Ponzoni A; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Troiani M; Ima Biotech, Lille, France.
  • Calì B; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Pasquini E; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
  • Attanasio G; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Mosole S; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Mirenda M; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • D'Ambrosio M; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Colucci M; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Guccini I; Evotec, Toulouse, France.
  • Revandkar A; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Alajati A; Imperial College London, London, UK.
  • Tebaldi T; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Donzel D; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Lauria F; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
  • Parhizgari N; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Valdata A; Harvard Medical School, Massachusetts General Hospital Cancer Center, Boston, MA, USA.
  • Maddalena M; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Calcinotto A; Department of Urology, Universitätklinikum Bonn, Bonn, Germany.
  • Bolis M; Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Rinaldi A; Institute of Biophysics, CNR Unit at Trento, Povo, Italy.
  • Barry S; Institute of Biophysics, CNR Unit at Trento, Povo, Italy.
  • Rüschoff JH; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Sabbadin M; Biosun Pharmed, Kordan, Iran.
  • Sumanasuriya S; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Crespo M; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Sharp A; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Yuan W; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
  • Grinu M; Bioinformatics Core Unit, Swiss Institute of Bioinformatics, Bellinzona, Switzerland.
  • Boyle A; Computational Oncology Unit, Department of Oncology, Istituto di Richerche Farmacologiche 'Mario Negri' IRCCS, Milano, Italy.
  • Miller C; Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Trotman L; IMED Oncology AstraZeneca, Li Ka Shing Centre, Cambridge, UK.
  • Delaleu N; Department of Pathology and Molecular Pathology, University Hospital Zurich (USZ), Zurich, Switzerland.
  • Fassan M; Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
  • Moch H; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
  • Viero G; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
  • de Bono J; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
  • Alimonti A; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
Nat Cancer ; 4(8): 1102-1121, 2023 08.
Article em En | MEDLINE | ID: mdl-37460872
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Proteínas Serina-Treonina Quinases Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Nat Cancer Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Proteínas Serina-Treonina Quinases Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Nat Cancer Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça