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Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Lax, Brianna M; Palmeri, Joseph R; Lutz, Emi A; Sheen, Allison; Stinson, Jordan A; Duhamel, Lauren; Santollani, Luciano; Kennedy, Alan; Rothschilds, Adrienne M; Spranger, Stefani; Sansom, David M; Wittrup, K Dane.
Afiliação
  • Lax BM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Palmeri JR; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Lutz EA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Sheen A; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Stinson JA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Duhamel L; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Santollani L; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Kennedy A; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Rothschilds AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Spranger S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Sansom DM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Wittrup KD; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Proc Natl Acad Sci U S A ; 120(31): e2300895120, 2023 08.
Article em En | MEDLINE | ID: mdl-37487077
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Neoplasias Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Neoplasias Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article