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Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-desmethyl naproxen metabolite but not the acyl glucuronide.
Thomson, Paul; Fragkas, Nik; Kafu, Laila M; Aithal, Guruprasad P; Lucena, M Isabel; Terracciano, Luigi; Meng, Xiaoli; Pirmohamed, Munir; Brees, Dominique; Kullak-Ublick, Gerd A; Odermatt, Alex; Hammond, Thomas; Kammüller, Michael; Naisbitt, Dean J.
Afiliação
  • Thomson P; Molecular& Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Fragkas N; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Kafu LM; Molecular& Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Aithal GP; NIHR Nottingham Biomedical Research Centre and Nottingham Digestive Diseases Centre, Translational Medical Sciences, West Block, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
  • Lucena MI; Unidad de Gestión Clínica de Aparato Digestivo y Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, CIBERehd, Malaga, Spain.
  • Terracciano L; Institute of Pathology, University Hospital Basel, Basel, Switzerland.
  • Meng X; Molecular& Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Pirmohamed M; Molecular& Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Brees D; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Kullak-Ublick GA; University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Odermatt A; Novartis Global Drug Development, Basel, Switzerland.
  • Hammond T; Division of Molecular & Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
  • Kammüller M; Division of Molecular & Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
  • Naisbitt DJ; Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, Cambridge, UK.
Allergy ; 79(1): 200-214, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37515456
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naproxeno / Doença Hepática Crônica Induzida por Substâncias e Drogas Limite: Humans Idioma: En Revista: Allergy Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naproxeno / Doença Hepática Crônica Induzida por Substâncias e Drogas Limite: Humans Idioma: En Revista: Allergy Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido