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Methodological Development and Applications of Tryptamine-Ynamide Cyclizations in Synthesizing Core Skeletons of Indole Alkaloids.
Yang, Lu; Hou, Anbin; Jiang, Qing; Cheng, Maosheng; Liu, Yongxiang.
Afiliação
  • Yang L; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
  • Hou A; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
  • Jiang Q; Institute of Drug Research in Medicine Capital of China, Benxi 117000, P. R. China.
  • Cheng M; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
  • Liu Y; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
J Org Chem ; 88(16): 11377-11391, 2023 Aug 18.
Article em En | MEDLINE | ID: mdl-37540141
ABSTRACT
Over the past two decades, synthetic strategies for synthesizing the skeletons of various indole alkaloids based on tryptamine-ynamide have been continuously developed and applied to the total syntheses or formal total syntheses of related molecules. In this synopsis, we summarized the cyclization pathways of tryptamine-ynamide under different catalytic conditions, emphasizing the reaction mechanism and applications in the syntheses of indole alkaloids.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2023 Tipo de documento: Article