Ru-catalyzed C-H activation/cyclization of oximes with sulfoxonium ylides to access isoquinolines.

Yang, Darun; Xu, Hongyan; Zhang, Xuejun; Hu, Yuntao; Huang, Decai; Zhao, Huaiqing

Yang, Darun; Xu, Hongyan; Zhang, Xuejun; Hu, Yuntao; Huang, Decai; Zhao, Huaiqing.

Afiliação

Yang D; School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong, 250022, P. R. China. chm_zhaohq@ujn.edu.cn.
Xu H; School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong, 250022, P. R. China. chm_zhaohq@ujn.edu.cn.
Zhang X; School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong, 250022, P. R. China. chm_zhaohq@ujn.edu.cn.
Hu Y; School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong, 250022, P. R. China. chm_zhaohq@ujn.edu.cn.
Huang D; School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong, 250022, P. R. China. chm_zhaohq@ujn.edu.cn.
Zhao H; School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong, 250022, P. R. China. chm_zhaohq@ujn.edu.cn.

Org Biomol Chem ; 21(33): 6750-6756, 2023 Aug 23.

Article em En | MEDLINE | ID: mdl-37554009

ABSTRACT

ABSTRACT

An external oxidant free Ru(II)-catalyzed C-H activation followed by an intermolecular annulation between oximes and sulfoxonium ylides has been developed. This transformation proceeds smoothly with a broad range of substrates, affording a series of isoquinoline derivatives in moderate to good yields. This protocol was successfully applied to the synthesis of moxaverine.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article

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