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Pathophysiological consequences and treatment strategy of obstructive jaundice.
Liu, Jun-Jian; Sun, Yi-Meng; Xu, Yan; Mei, Han-Wei; Guo, Wu; Li, Zhong-Lian.
Afiliação
  • Liu JJ; Department of Hepatobiliary and Pancreatic Surgery, Tianjin Medical University Nankai Hospital, Tianjin 300102, China.
  • Sun YM; Graduate School, Tianjin Medical University, Tianjin 300070, China.
  • Xu Y; Graduate School, Tianjin Medical University, Tianjin 300070, China.
  • Mei HW; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
  • Guo W; Graduate School, Tianjin Medical University, Tianjin 300070, China.
  • Li ZL; Department of Hepatobiliary and Pancreatic Surgery, Tianjin Medical University Nankai Hospital, Tianjin 300102, China. nkyylzl@163.com.
World J Gastrointest Surg ; 15(7): 1262-1276, 2023 Jul 27.
Article em En | MEDLINE | ID: mdl-37555128
ABSTRACT
Obstructive jaundice (OJ) is a common problem in daily clinical practice. However, completely understanding the pathophysiological changes in OJ remains a challenge for planning current and future management. The effects of OJ are widespread, affecting the biliary tree, hepatic cells, liver function, and causing systemic complications. The lack of bile in the intestine, destruction of the intestinal mucosal barrier, and increased absorption of endotoxins can lead to endotoxemia, production of proinflammatory cytokines, and induce systemic inflammatory response syndrome, ultimately leading to multiple organ dysfunction syndrome. Proper management of OJ includes adequate water supply and electrolyte replacement, nutritional support, preventive antibiotics, pain relief, and itching relief. The surgical treatment of OJ depends on the cause, location, and severity of the obstruction. Biliary drainage, surgery, and endoscopic intervention are potential treatment options depending on the patient's condition. In addition to modern medical treatments, Traditional Chinese medicine may offer therapeutic benefits for OJ. A comprehensive search was conducted on PubMed for relevant articles published up to August 1970. This review discusses in detail the pathophysiological changes associated with OJ and presents effective strategies for managing the condition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: World J Gastrointest Surg Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: World J Gastrointest Surg Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China