Knockdown of BUB1 inhibits tumor necrosis factor-&#945;-induced proliferation and migration of rheumatoid arthritis synovial fibroblasts by regulating PI3K/Akt pathway.

He, Qian; Jia, Lanlan; Wang, Xiaowan; Feng, Dandan; Mao, Tongjun

Knockdown of BUB1 inhibits tumor necrosis factor-α-induced proliferation and migration of rheumatoid arthritis synovial fibroblasts by regulating PI3K/Akt pathway.

He, Qian; Jia, Lanlan; Wang, Xiaowan; Feng, Dandan; Mao, Tongjun.

Afiliação

He Q; Department of Rheumatism and Immunology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Jia L; Department of Rheumatism and Immunology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Wang X; Department of Rheumatism and Immunology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Feng D; Department of Rheumatism and Immunology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Mao T; Department of Rheumatism and Immunology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.

Int J Rheum Dis ; 26(10): 2024-2030, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37593912

Assuntos

Artrite Reumatoide; Fator de Necrose Tumoral alfa; Humanos; Fator de Necrose Tumoral alfa/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Fosfatidilinositol 3-Quinases/farmacologia; Transdução de Sinais; Artrite Reumatoide/metabolismo; Citocinas/metabolismo; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas Serina-Treonina Quinases/farmacologia; Proliferação de Células; Fibroblastos/metabolismo; Serina/metabolismo; Serina/farmacologia

Palavras-chave

BUB1; MH7A cell; PI3K/Akt pathway; rheumatoid arthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Fator de Necrose Tumoral alfa Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Rheum Dis Assunto da revista: REUMATOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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