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BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis.
Acosta-Medina, Aldo A; Kemps, Paul G; Zondag, Timo C E; Abeykoon, Jithma P; Forma-Borst, Jelske; Steenwijk, Eline C; Feijen, Elizabeth A M; Teepen, Jop C; Bennani, N Nora; Schram, Susan M; Shah, Mithun V; Davidge-Pitts, Caroline; Koster, Matthew J; Ryu, Jay H; Vassallo, Robert; Tobin, W Oliver; Young, Jason R; Dasari, Surendra; Rech, Karen; Ravindran, Aishwarya; Cleven, Arjen H G; Verdijk, Robert M; van Noesel, Carel J M; Balgobind, Brian V; Bouma, Gerrit Joan; Saeed, Peerooz; Bramer, Jos A M; de Groen, Ruben A L; Vermaat, Joost S P; van de Sande, Michiel A J; Smit, Egbert F; Langerak, Anton W; van Wezel, Tom; Tonino, Sanne H; van den Bos, Cor; van Laar, Jan A M; Go, Ronald S; Goyal, Gaurav; van Halteren, Astrid G S.
Afiliação
  • Acosta-Medina AA; Department of Internal Medicine, Mayo Clinic, Rochester, MN.
  • Kemps PG; Division of Hematology, Mayo Clinic, Rochester, MN.
  • Zondag TCE; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
  • Abeykoon JP; Section Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Forma-Borst J; Division of Hematology, Mayo Clinic, Rochester, MN.
  • Steenwijk EC; Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
  • Feijen EAM; Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
  • Teepen JC; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
  • Bennani NN; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
  • Schram SM; Division of Hematology, Mayo Clinic, Rochester, MN.
  • Shah MV; Division of Hematology, Mayo Clinic, Rochester, MN.
  • Davidge-Pitts C; Division of Hematology, Mayo Clinic, Rochester, MN.
  • Koster MJ; Division of Endocrinology, Mayo Clinic, Rochester, MN.
  • Ryu JH; Division of Rheumatology, Mayo Clinic, Rochester, MN.
  • Vassallo R; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
  • Tobin WO; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
  • Young JR; Department of Neurology, Mayo Clinic, Rochester, MN.
  • Dasari S; Department of Radiology, Mayo Clinic, Jacksonville, FL.
  • Rech K; Division of Biomedical Statistics and Informatics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
  • Ravindran A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
  • Cleven AHG; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL.
  • Verdijk RM; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
  • van Noesel CJM; Department of Pathology, University Medical Center Groningen, Groningen, The Netherlands.
  • Balgobind BV; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
  • Bouma GJ; Department of Pathology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Saeed P; Department of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • Bramer JAM; Department of Radiation Oncology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • de Groen RAL; Department of Neurosurgery, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • Vermaat JSP; Department of Ophthalmology, Orbital Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • van de Sande MAJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
  • Smit EF; Department of Orthopedic Surgery and Sports Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • Langerak AW; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
  • van Wezel T; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
  • Tonino SH; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
  • van den Bos C; Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands.
  • van Laar JAM; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
  • Go RS; Department of Immunology, Laboratory Medical Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Goyal G; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
  • van Halteren AGS; Department of Hematology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Blood ; 142(18): 1570-1575, 2023 11 02.
Article em En | MEDLINE | ID: mdl-37595284
ABSTRACT
In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histiocitose de Células de Langerhans / Segunda Neoplasia Primária Tipo de estudo: Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Blood Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Mongólia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histiocitose de Células de Langerhans / Segunda Neoplasia Primária Tipo de estudo: Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Blood Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Mongólia