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Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.
Crivelli, Simone M; Quadri, Zainuddin; Vekaria, Hemendra J; Zhu, Zhihui; Tripathi, Priyanka; Elsherbini, Ahmed; Zhang, Liping; Sullivan, Patrick G; Bieberich, Erhard.
Afiliação
  • Crivelli SM; Department of Physiology, University of Kentucky College of Medicine, 780 Rose Street MS519, Lexington, KY, 40536, USA.
  • Quadri Z; Department of Physiology, University of Kentucky College of Medicine, 780 Rose Street MS519, Lexington, KY, 40536, USA.
  • Vekaria HJ; Department of Neuroscience, University of Kentucky, Lexington, KY, 40536, USA.
  • Zhu Z; Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky, Lexington, KY, USA.
  • Tripathi P; Veterans Affairs Medical Center, Lexington, KY, 40502, USA.
  • Elsherbini A; Department of Physiology, University of Kentucky College of Medicine, 780 Rose Street MS519, Lexington, KY, 40536, USA.
  • Zhang L; Department of Physiology, University of Kentucky College of Medicine, 780 Rose Street MS519, Lexington, KY, 40536, USA.
  • Sullivan PG; Department of Physiology, University of Kentucky College of Medicine, 780 Rose Street MS519, Lexington, KY, 40536, USA.
  • Bieberich E; Department of Physiology, University of Kentucky College of Medicine, 780 Rose Street MS519, Lexington, KY, 40536, USA.
Acta Neuropathol Commun ; 11(1): 135, 2023 08 21.
Article em En | MEDLINE | ID: mdl-37605262
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Vesículas Extracelulares Limite: Animals Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Vesículas Extracelulares Limite: Animals Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos