Analysis of subcellular RNA fractions demonstrates significant genetic regulation of gene expression in human brain post-transcriptionally.

D'Sa, Karishma; Guelfi, Sebastian; Vandrovcova, Jana; Reynolds, Regina H; Zhang, David; Hardy, John; Botía, Juan A; Weale, Michael E; Taliun, Sarah A Gagliano; Small, Kerrin S; Ryten, Mina

D'Sa, Karishma; Guelfi, Sebastian; Vandrovcova, Jana; Reynolds, Regina H; Zhang, David; Hardy, John; Botía, Juan A; Weale, Michael E; Taliun, Sarah A Gagliano; Small, Kerrin S; Ryten, Mina.

Afiliação

D'Sa K; Department of Neurodegenerative Disease, University College London, London, WC1N 3BG, UK.
Guelfi S; Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 1UL, UK.
Vandrovcova J; Department of Clinical and Movement Neurosciences, University College London, London, WC1N 3BG, UK.
Reynolds RH; Department of Neurodegenerative Disease, University College London, London, WC1N 3BG, UK.
Zhang D; Verge Genomics, Tower Pl, South San Francisco, CA, 94080, USA.
Hardy J; Dept of Neuromuscular Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.
Botía JA; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, WC1N 1EH, UK.
Weale ME; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, WC1N 1EH, UK.
Taliun SAG; Department of Neurodegenerative Disease, University College London, London, WC1N 3BG, UK.
Small KS; UK Dementia Research Institute at University College London, London, WC1N 3BG, UK.
Ryten M; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, WC1N 1EH, UK.

Sci Rep ; 13(1): 13874, 2023 08 24.

Article em En | MEDLINE | ID: mdl-37620324

Assuntos

Regulação da Expressão Gênica; Estudo de Associação Genômica Ampla; Humanos; Frações Subcelulares; Núcleo Solitário; RNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido

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