Design, synthesis and biological evaluation of 4-arylamino-pyrimidine derivatives as focal adhesion kinase inhibitors.

Long, Zhiwu; Zuo, Yaqing; Li, Rongrong; Le, Yi; Dong, Yawen; Yan, Longjia

Long, Zhiwu; Zuo, Yaqing; Li, Rongrong; Le, Yi; Dong, Yawen; Yan, Longjia.

Afiliação

Long Z; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China.
Zuo Y; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China.
Li R; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China.
Le Y; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China; Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550025, China.
Dong Y; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China; National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China.
Yan L; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China; Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550025, China. Electronic address: ylj1089@163.com.

Bioorg Chem ; 140: 106792, 2023 11.

Article em En | MEDLINE | ID: mdl-37633129

Assuntos

Anti-Hipertensivos; Apoptose; Humanos; Proteína-Tirosina Quinases de Adesão Focal; Simulação de Acoplamento Molecular; Fosforilação

Palavras-chave

Antitumor; FAK inhibitor; Pyrimidine; Thiophene

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Anti-Hipertensivos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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