Enhancing the properties of electrospun polyvinyl Alcohol/Oxidized sodium alginate nanofibers with fluorescence carbon Dots: Preparation and characterization.
Int J Pharm
; 644: 123358, 2023 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-37647981
ABSTRACT
The objective of this study was to develop fluorescence nanofibrous polyvinyl alcohol/oxidized sodium alginate (PVA-OSA) incorporated with carbon dots (CDs) through Schiff-base interaction. The carbon dots used in this study were derived from the polyphenol-enriched extract of pomegranate peel, as established in previous work, as the reinforcing and antioxidant agent to enhance the physicochemical and biological properties of the nanofibers were used. The fabricated nanofibers were characterized using FE-SEM, FT-IR, XRD, and DSC analysis. The FE-SEM results revealed that an increase in the number of CDs in the nanofibers led to a decrease in diameter (809.6 ± 77.1 nm to 273.16 ± 41.1 nm). Furthermore, surface modification caused a significant reduction in the amount of surface roughness of the nanofibers. Incorporating CDs not only reduced the scaffold diameter but also improved its mechanical properties and promoted the growth of fibroblast cells. The ultimate tensile strength of scaffolds with and without CDs was 2.15 ± 0.02 MPa and 1.53 ± 0.74 MPa respectively. The influence of CDs amount on the properties of nanofibers showed that the swelling capacity and degradability of nanofibers can be adjusted by changing the range of CDs. Apart from the aforementioned benefits of incorporating CDs in improving nanofiber properties, their exceptional antioxidant properties can be harnessed for protecting nanofibers against oxidation and as a healing agent in wound dressings.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nanofibras
/
Antioxidantes
Idioma:
En
Revista:
Int J Pharm
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Irã