Synthesis and clinical application of small-molecule inhibitors and PROTACs of anaplastic lymphoma kinase.

Gao, Hua; Zhang, Jing-Yi; Zhao, Li-Jie; Guo, Yuan-Yuan

Gao, Hua; Zhang, Jing-Yi; Zhao, Li-Jie; Guo, Yuan-Yuan.

Afiliação

Gao H; Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhang JY; The Rogel Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States; College of Chemistry and Chemical Engineering, Zhengzhou Normal University 450044, China. Electronic address: zhangjingyi@zznu.edu.cn.
Zhao LJ; The Rogel Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: lijiez1113@outlook.com.
Guo YY; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou 450052, China. Electronic address: kobe91f@163.com.

Bioorg Chem ; 140: 106807, 2023 11.

Article em En | MEDLINE | ID: mdl-37651895

Assuntos

Proteínas Tirosina Quinases; Quimera de Direcionamento de Proteólise; Humanos; Quinase do Linfoma Anaplásico; Fosforilação; Proteínas do Citoesqueleto; Inibidores de Proteínas Quinases/farmacologia

Palavras-chave

ALK; Application; Cancer; Drugs; Synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Quimera de Direcionamento de Proteólise Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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