[Reproductive activity of the influenza A virus in the splenocytes of experimental animals with mono- and mixed infections]. / Reproduktsionnaia aktivnost' virusa grippa A v splenotsitakh éksperimental'nykh zhivotnykh pri mono- i smeshannoi infektsii.

ABSTRACT

Virus-induced processes in organs and tissues of Syrian hamsters in relation to the influenza A virus strain used (HON1 or H3N2), age of the animals, and in the presence of mixed infection were compared. The infection of young hamsters with A/PR8/34 and A/Bangkok/1/79 viruses was shown to induce the synthesis of viral proteins NP and M in spleen cells lasting for up to 15 days (the observation period). In mixed influenza and respiratory syncytial virus infection the possibility of influenza virus genome expression did not change. After infection of mature hamsters, synthesis of virus-specific NP and M proteins in splenocytes was observed only in the animals infected with influenza A/PR8/34 virus but not in those infected with the less pathogenic influenza A/Bangkok/1/79 virus.