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Association between metabolic syndrome and risk of incident dementia in UK Biobank.
Qureshi, Danial; Collister, Jennifer; Allen, Naomi E; Kuzma, Elzbieta; Littlejohns, Thomas.
Afiliação
  • Qureshi D; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Collister J; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Allen NE; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Kuzma E; UK Biobank Ltd, Stockport, UK.
  • Littlejohns T; Albertinen Haus Centre for Geriatrics and Gerontology, University of Hamburg, Hamburg, Germany.
Alzheimers Dement ; 20(1): 447-458, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37675869
INTRODUCTION: The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. METHODS: In 176,249 dementia-free UK Biobank participants aged ≥60 years at baseline, Cox proportional-hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high-density lipoprotein cholesterol. RESULTS: Over 15 years of follow-up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow-up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein-E (APOE)-ε4 non-carriers. DISCUSSION: In this large population-based prospective cohort, MetS was associated with an increased risk of dementia. HIGHLIGHTS: MetS was associated with a 12% increased risk of incident all-cause dementia. Associations remained similar after restricting the analysis to those with longer follow-up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Metabólica / Demência Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Alzheimers Dement Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Metabólica / Demência Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Alzheimers Dement Ano de publicação: 2024 Tipo de documento: Article