Asparagine endopeptidase protects podocytes in adriamycin-induced nephropathy by regulating actin dynamics through cleaving transgelin.

Qiu, Yang; Lei, Chuntao; Zeng, Jieyu; Xie, Yaru; Cao, Yiling; Yuan, Qian; Su, Hua; Zhang, Zhentao; Zhang, Chun

Qiu, Yang; Lei, Chuntao; Zeng, Jieyu; Xie, Yaru; Cao, Yiling; Yuan, Qian; Su, Hua; Zhang, Zhentao; Zhang, Chun.

Afiliação

Qiu Y; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
Lei C; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
Zeng J; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
Xie Y; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
Cao Y; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
Yuan Q; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
Su H; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China.
Zhang C; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China. Electronic address: drzhangchun@hust.edu.cn.

Mol Ther ; 31(11): 3337-3354, 2023 11 01.

Article em En | MEDLINE | ID: mdl-37689970

Assuntos

Cisteína Endopeptidases; Glomerulosclerose Segmentar e Focal; Nefropatias; Podócitos; Animais; Humanos; Camundongos; Actinas/genética; Actinas/metabolismo; Doxorrubicina/efeitos adversos; Glomerulosclerose Segmentar e Focal/induzido quimicamente; Glomerulosclerose Segmentar e Focal/genética; Glomerulosclerose Segmentar e Focal/metabolismo; Nefropatias/metabolismo; Camundongos Knockout; Proteínas dos Microfilamentos/genética; Proteínas dos Microfilamentos/metabolismo; Podócitos/metabolismo; Proteinúria/metabolismo; Proteinúria/patologia; Cisteína Endopeptidases/genética

Palavras-chave

asparagine endopeptidase; cytoskeletal dynamics; focal segmental glomerulosclerosis; lysosomal protease; podocyte injury; transgelin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cisteína Endopeptidases / Glomerulosclerose Segmentar e Focal / Podócitos / Nefropatias Limite: Animals / Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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