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Diagnostic concordance between traditional and digital workflows. A study on 1427 prostate biopsies.
Torresani, Evelin; Gentilini, Maria Adalgisa; Grassi, Stefano; Cima, Luca; Pedrolli, Irene; Cai, Tommaso; Puglisi, Marco; Vattovani, Valentino; Guadin, Bianca; Brunelli, Matteo; Doglioni, Claudio; Barbareschi, Mattia.
Afiliação
  • Torresani E; Unit of Surgical Pathology, Santa Chiara Hospital, APSS, Trento, Italy.
  • Gentilini MA; Epidemiology and Clinical Evaluation Unit, APSS, Trento, Italy.
  • Grassi S; Department Pathology, Vita e salute University, San Raffaele Hospital, Milano, Italy.
  • Cima L; Unit of Surgical Pathology, Santa Chiara Hospital, APSS, Trento, Italy.
  • Pedrolli I; Unit of Surgical Pathology, Santa Chiara Hospital, APSS, Trento, Italy.
  • Cai T; Unit of Urology, Santa Chiara Hospital, APSS, Trento, Italy.
  • Puglisi M; Unit of Urology, Santa Chiara Hospital, APSS, Trento, Italy.
  • Vattovani V; Unit of Urology, Santa Chiara Hospital, APSS, Trento, Italy.
  • Guadin B; Experimental and Applied Biology, University of Pavia, Italy.
  • Brunelli M; Pathology Unit, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy.
  • Doglioni C; Department Pathology, Vita e salute University, San Raffaele Hospital, Milano, Italy.
  • Barbareschi M; Unit of Surgical Pathology, Santa Chiara Hospital, APSS, Trento, Italy.
Pathologica ; 115(4): 221-226, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37711038
Objective: To evaluate intra-observer diagnostic reproducibility using traditional slides (TS) versus whole slide images (WSI). Methods: TS and WSI of 1427 prostatic biopsies (107 consecutive patients) were evaluated by a single pathologist. Agreement between readings was evaluated with Gwet's Agreement coefficient (AC) and Landis and Koch benchmark scale. Results: The positive/negative agreement between the readings was almost perfect (AC1= 0.962; 95% CI[0.949,0.974]), with method independent distribution of discrepancies. Among positive biopsies, 212 had identical Gleason score (GS) on TS and WSI and discordant GS in 69 cases (AC2 = 0.932; 95% CI[0.907, 0.956]). Concordant negative and positive patient classification was observed in 39 and 64 cases, respectively; two cases were assigned to the positive group on TS and 2 on WSI configuring an almost perfect agreement (AC1=0.929; 95% C1[0.860, 0.998]). ISUP Grade group (ISUP GG) agreement was evaluated in the 60 concordantly positive cases: in 45 cases it was identical on TS and WSI; in 10 biopsies the discrepancy implied a modification of the assigned ISUP GG of ≤ 1 class and in 5 the discrepancy implied a modification of 2 classes. Gwet's agreement coefficient was (95% CI [0.834, 0.962]), i.e.: almost perfect agreement. Conclusions: Our data show almost perfect agreement between digital and traditional diagnostic activity in a routine setting, confirming that digital pathology can be safely introduced into routine workflows.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Patologistas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans / Male Idioma: En Revista: Pathologica Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Patologistas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans / Male Idioma: En Revista: Pathologica Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália