Recent Advances in Understanding the Human Fungal Pathogen Hypoxia Response in Disease Progression.
Annu Rev Microbiol
; 77: 403-425, 2023 09 15.
Article
em En
| MEDLINE
| ID: mdl-37713457
ABSTRACT
Fungal-mediated disease progression and antifungal drug efficacy are significantly impacted by the dynamic infection microenvironment. At the site of infection, oxygen often becomes limiting and induces a hypoxia response in both the fungal pathogen and host cells. The fungal hypoxia response impacts several important aspects of fungal biology that contribute to pathogenesis, virulence, antifungal drug susceptibility, and ultimately infection outcomes. In this review, we summarize recent advances in understanding the molecular mechanisms of the hypoxia response in the most common human fungal pathogens, discuss potential therapeutic opportunities, and highlight important areas for future research.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipóxia
/
Antifúngicos
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Microbiol
Ano de publicação:
2023
Tipo de documento:
Article