Your browser doesn't support javascript.
loading
Wulfenioidins D-N, Structurally Diverse Diterpenoids with Anti-Zika Virus Activity Isolated from Orthosiphon wulfenioides.
Tu, Wen-Chao; Huang, Yong-Xiang; Li, Bo; Jiang, Ying-Jie; Yang, Quan-Yu; Zeb, Muhammad Aurang; Yang, Peng-Yun; Wang, Hui-Juan; Li, Xiao-Li; Xiao, Wei-Lie; Zheng, Chang-Bo; Liu, Mei-Feng.
Afiliação
  • Tu WC; Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, People's Republic of China.
  • Huang YX; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School
  • Li B; School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Yunnan Vaccine Laboratory, Kunming Medical University, Kunming, 650500, People's Republic of China.
  • Jiang YJ; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School
  • Yang QY; School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Yunnan Vaccine Laboratory, Kunming Medical University, Kunming, 650500, People's Republic of China.
  • Zeb MA; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School
  • Yang PY; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School
  • Wang HJ; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School
  • Li XL; Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, People's Republic of China.
  • Xiao WL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School
  • Zheng CB; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School
  • Liu MF; School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Yunnan Vaccine Laboratory, Kunming Medical University, Kunming, 650500, People's Republic of China.
J Nat Prod ; 86(10): 2348-2359, 2023 10 27.
Article em En | MEDLINE | ID: mdl-37737089
Eleven diterpenoids, wulfenioidins D-N (1-11), classified into five distinct carbon skeletons with one unreported framework, and four modified abietane diterpenoids were isolated from the whole plant of Orthosiphon wulfenioides. The structures and absolute configurations were characterized by spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism analyses. Compounds 3 and 5 exhibited activity against Zika virus (ZIKV) with EC50 values of 8.07 and 8.50 µM, respectively, and showed no significant cytotoxicity toward Vero cells at 100 µM. Western blot and immunofluorescence experiments showed that compounds 3 and 5 interfered with the replication of the ZIKV by inhibiting the expression of the ZIKV envelope (E) protein.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthosiphon / Diterpenos / Zika virus / Infecção por Zika virus Limite: Animals Idioma: En Revista: J Nat Prod Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthosiphon / Diterpenos / Zika virus / Infecção por Zika virus Limite: Animals Idioma: En Revista: J Nat Prod Ano de publicação: 2023 Tipo de documento: Article