Cathepsin C role in inflammatory gastroenterological, renal, rheumatic, and pulmonary disorders.
Biochimie
; 216: 175-180, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37758158
ABSTRACT
Cathepsin C (CatC, syn. Dipeptidyl peptidase I) is a lysosomal cysteine proteinase expressed in several tissues including inflammatory cells. This enzyme is important for maintaining multiple cellular functions and for processing immune cell-derived proteases. While mutations in the CatC gene were reported in Papillon-Lefèvre syndrome, a rare autosomal recessive disorder featuring hyperkeratosis and periodontitis, evidence from clinical and preclinical studies points toward pro-inflammatory effects of CatC in various disease processes that are mainly mediated by the activation of neutrophil serine proteinases. Moreover, tumor-promoting effects were ascribed to CatC. The aim of this review is to highlight current knowledge of the CatC as a potential therapeutic target in inflammatory disorders.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Papillon-Lefevre
/
Pneumopatias
Limite:
Humans
Idioma:
En
Revista:
Biochimie
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha