Syringin Prevents 6-Hydroxydopamine Neurotoxicity by Mediating the MiR-34a/SIRT1/Beclin-1 Pathway and Activating Autophagy in SH-SY5Y Cells and the <i>Caenorhabditis elegans</i> Model.

Fu, Ru-Huei; Hong, Syuan-Yu; Chen, Hui-Jye

Syringin Prevents 6-Hydroxydopamine Neurotoxicity by Mediating the MiR-34a/SIRT1/Beclin-1 Pathway and Activating Autophagy in SH-SY5Y Cells and the Caenorhabditis elegans Model.

Fu, Ru-Huei; Hong, Syuan-Yu; Chen, Hui-Jye.

Afiliação

Fu RH; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Hong SY; Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Chen HJ; Ph.D. Program for Aging, China Medical University, Taichung 40402, Taiwan.

Cells ; 12(18)2023 09 19.

Article em En | MEDLINE | ID: mdl-37759532

Assuntos

MicroRNAs; Neuroblastoma; Síndromes Neurotóxicas; Doença de Parkinson; Humanos; Animais; Oxidopamina/farmacologia; Caenorhabditis elegans; alfa-Sinucleína; Proteína Beclina-1; Sirtuína 1/genética; Autofagia; MicroRNAs/genética

Palavras-chave

6-hydroxydopamine (6-OHDA); Beclin-1; C. elegans; Parkinson's disease; SH-SY5Y cells; SIRT1; autophagy; miR-34a; syringin; α-synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Síndromes Neurotóxicas / MicroRNAs / Neuroblastoma Limite: Animals / Humans Idioma: En Revista: Cells Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Taiwan

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