Pulmonary Sarcoidosis and Immune Dysregulation: A Pilot Study on Possible Correlation.
Diagnostics (Basel)
; 13(18)2023 Sep 11.
Article
em En
| MEDLINE
| ID: mdl-37761266
ABSTRACT
BACKGROUND:
Sarcoidosis is a systemic inflammatory disease characterized by an altered inflammatory response.OBJECTIVE:
The aim of this study was to evaluate whether immune system alterations detected by lymphocyte typing in peripheral blood correlate with the severity of sarcoidosis, calculated according to two separate severity scores proposed by Wasfi in 2006 and Hamzeh in 2010. MATERIALS ANDMETHODS:
Eighty-one patients were recruited, and clinical data and laboratory tests at the time of diagnosis were obtained in order to assess the severity index score and investigate any statistically significant correlation with the cytofluorimetry data.RESULTS:
Our data demonstrated that none of the two scores show an association with the level of total lymphocytes or lymphocyte subclasses.LIMITATIONS:
First of all, the sample taken into consideration is small. The assessment was performed only at disease onset and not during the disease. Furthermore, the severity scores do not take into account disease activity (measured by PET/CT or gallium scintigraphy).CONCLUSIONS:
Lymphocyte subpopulation values at the time of diagnosis do not appear to correlate with disease severity at onset.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Diagnostics (Basel)
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália